![]() (2012) Laminar circuit organization and response modulation in mouse visual cortex. Olivas, N.D., Quintanar-Zilinskas, V., Nenadic, Z., Xu, X. (2010) Novel use of matched filtering for synaptic event detection and extraction. Journal of Neurophysiology 103, 2301 – 2312. (2010) High resolution and fast functional mapping of cortical circuitry through a novel combination of voltage sensitive dye imaging and laser scanning photostimulation. Xu, X.*, Olivas, N.D., Levi, R., Ikrar, T., Nenadic, Z. Our recent directions include 1) using the latest single cell genomic technologies coupled with functional circuit mapping and behavioral analysis to determine how the transcriptome and epigenome shape neural circuit activity and learning and memory behaviors that change with aging and AD progression 2) applying our findings towards treating Alzheimer’s disease based on our conceptual advances in circuit manipulation-based strategies in AD animal models. Our research work has significant potential for translational applications for better treatments of neurodevelopmental disorders and neurological diseases. ![]() Our research is focused on understanding cell-type specific cortical circuit organization and function, using combined approaches of electrophysiology, optical stimulation and imaging, molecular genetics and viral tracing. This is also key to understanding the mechanistic basis of neurological disorders. Understanding how neural circuits give rise to perception, cognition, and behavior is central to understanding how the brain works. Xu's interests are in neural circuitry, which applies to understanding the neurobiology of sensory perception, learning and memory, stress, and epilepsy. Herrick Award in Neuroanatomy of the American Association of AnatomistsĠ9/2013 Recipient of the 2013 Krieg Cortical Explorer Award, the Cajal Club FoundationĠ4/2013 2013 Randolph Blake Early Career Award, Vanderbilt UniversityĠ8/2012 2012 NARSAD Young Investigator Award, Brain & Behavior Research FoundationĢ010-2011 The Best 1st Year Course Award from the Association of Students, UCI School of Medicine ġ2/2006 NIH Pathway to Independence Award (K99/R00), National Institute on Drug Abuse / NIHġ1/2004 Kreig Cortical Kudos Award (Cortical Scholar Award), the Cajal Club / Society for NeuroscienceĠ9/1998 - 06/1999 University Scholarship & Fellowship, Vanderbilt Universityĭr. 12/2023 Awarded the title of Chancellor's Professor, University of California, IrvineĠ4/2023 Outstanding Mid-Career Faculty Research Award, School of Medicine, UCIġ2/2021 Samueli Scholar 2021, Susan and Henry Samueli College of Health Sciences, UCIĠ7/2020 Awarded the title of Chancellor’s Fellow, University of California, IrvineĠ7/2020 – 06/2024 Standing Member, Pathophysiological Basis of Mental Disorders and Addictions Study Section (PMDA), Center for Scientific Review, National Institutes of HealthĠ4/2014 Recipient of the 2014 C.
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